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Some possible triggers may include: Using two separate drugs to shed weight can be very effective you will find combinations as you're watching FDA now awaiting approval. When dealing with weight loss and the people that go through it you need to err to the side of caution and permit the FDA do its job and demand some study be done so the public recognizes the side effects and risks of the medications before we take them. Keep in mind that drug companies will be in business to make money and that they would say almost anything to keep people on their medications. Researchers found that participants investing in this drug for a year, lost excess weight within one month and have kept the extra weight off throughout the 56 weeks in the study. Contrave is a combination from the drugs naltrexone and bupropion, which seems to reflect a brand new trend of weight-loss drugs which are made up of several active ingredient, which can make them more effective and safer. Combo-pilling may be the newest fad or in addition to this the newest into the future under scrutiny and for that reason it is just more publicly known in recent months, comb-pilling to lose weight has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular will be the fact that by right now there aren't any long term prescription weight loss supplements that have been approved by the FDA apart from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications and some of the combinations happen to be rejected or have yet to be authorized by the FDA. Seizures certainly are a side effect with Contrave and shouldn't be taken in individuals with seizure disorders. The drug can also raise hypertension and heartrate, and really should not be used in people with a history of cardiac event or stroke in the previous six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with all the drug. The FDA also warned that Contrave can raise blood pressure levels and pulse rate and must 't be used in patients with uncontrolled high blood pressure level, and also by anyone with heart-related and cerebrovascular (blood vessel dysfunction impacting the brain) disease. Patients which has a history of cardiac event or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes having a boxed warning to alert physicians and patients for the increased probability of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for stopping smoking. Acamprosate also functions eliminate the wish to drink by reducing the the cravings for alcohol consumption. The major difference between Naltrexone and Acamprosate is Acamprosate just isn't yet available in the United States. While it has become widely studied in Europe the precise chemical belief that it works remains to be unknown. It is thought that it inhibits receptors inside the brain which process glutamate, which essentially alters the way in which ones body reacts to alcohol intake. Several of the European research has shown a lot of promise with Acamprosate in that some of the patients had a virtually double rate of success for staying sober.